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C Thomas Appleton Selected Research

Knee Osteoarthritis

1/2023Human osteoarthritis knee joint synovial fluids cleave and activate Proteinase-Activated Receptor (PAR) mediated signaling.
1/2023Changes and Associations Between Gait Biomechanics and Knee Inflammation After Aspiration and Glucocorticoid Injection for Knee Osteoarthritis.
1/2023Responders to Medial Opening Wedge High Tibial Osteotomy for Knee Osteoarthritis.
1/2022Sex-Differences and Associations Between Complement Activation and Synovial Vascularization in Patients with Late-Stage Knee Osteoarthritis.
7/2020Are we missing the target? Are we aiming too low? What are the aerobic exercise prescriptions and their effects on markers of cardiovascular health and systemic inflammation in patients with knee osteoarthritis? A systematic review and meta-analysis.
7/2019Degenerative Meniscal Tears and High Tibial Osteotomy: Do Current Treatment Algorithms Need to Be Realigned?

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C Thomas Appleton Research Topics

Disease

6Knee Osteoarthritis
01/2023 - 07/2019
5Inflammation (Inflammations)
03/2024 - 07/2020
2Osteoarthritis
10/2023 - 01/2021
2Pain (Aches)
01/2023 - 07/2019
2Necrosis
07/2020 - 08/2014
1Fibrosis (Cirrhosis)
03/2024
1Synovitis
01/2023
1Familial Mediterranean Fever (Periodic Disease)
04/2022
1Vascular Diseases (Vascular Disease)
04/2022
1Cardiovascular Diseases (Cardiovascular Disease)
04/2022
1Amyloidosis
04/2022

Drug/Important Bio-Agent (IBA)

1Macrophage Colony-Stimulating FactorIBA
10/2023
1Peptide Hydrolases (Proteases)FDA Link
01/2023
1GlucocorticoidsIBA
01/2023
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
01/2023
1Proteinase-Activated ReceptorsIBA
01/2023
1AA amyloidosisIBA
04/2022
1Biomarkers (Surrogate Marker)IBA
04/2022
1Fibroblast Growth Factor-23IBA
04/2022
1Complement System Proteins (Complement)IBA
01/2022
1PolymersIBA
01/2021
1Coe Comfort (FITT)IBA
07/2020
1Interleukin-6 (Interleukin 6)IBA
07/2020
1N,N-bis(methylmercury)-4-toluene sulfamideIBA
07/2019
1Messenger RNA (mRNA)IBA
08/2014
1Metalloproteases (Metalloproteinases)IBA
08/2014

Therapy/Procedure

2Osteotomy
01/2023 - 07/2019
1Pain Management
03/2024